welcome to DuchenneXchange
- a positively charged Duchenne muscular dystrophy community.- join today!
- log in
Antisense Therapeutics Announces Positive Results from Phase 2 Study of ATL1102 in DMD
Australian company Antisense Therapeutics announced encouraging results from its phase 2, open-label clinical trial of the company’s investigational therapy ATL1102 for treating Duchenne muscular dystrophy (DMD). The study met its primary endpoint, which was to assess the safety and tolerability of ATL1102 in patients with DMD who are non-ambulatory (unable to walk independently).
After six months of weekly, subcutaneous treatment with a low dose, the drug appeared to be safe and well tolerated in all participants with only minor side effects. Secondary endpoint results also seemed encouraging, as the drug lowered the average number of specific immune cells during the treatment period and largely improved measurements of functional capacity in seven of nine boys treated.
DMD is a genetic disease caused by a mutation in the dystrophin gene on the X chromosome that results in little or no production of dystrophin, an essential protein for keeping muscle cells intact.
rareRelated
-
A safety and efficacy study of ATL1102 in patients with Duchenne muscular dystrophyCurrent DMD therapies are aimed at incre...
-
First Patient Dosed in Phase II Clinical Trial in Duchenne Muscular DystrophyAntisense Therapeutics today announced d...
-
Antisense Therapeutics to commence muscular dystrophy trialsAntisense Therapeutics is planning to un...
-
Open Label Extension Study of HT-100 in Patients With DMDThis study is designed to provide 6-mont...
-
New Drug for Duchenne Muscular Dystrophy Clears Phase 1 Clinical Trial Testing in BoysPatients with Duchenne muscular dystroph...
-
MoveDMD: phase 2 trial of edasalonexent, an NF-κB inhibitor, in 4 to 7-year old patients with Duchenne muscular dys...NF-κB is activated from infancy in DMD,...
