welcome to DuchenneXchange

- a positively charged Duchenne muscular dystrophy community.
  • join today!

Capricor Therapeutics Expands Exosome Technology for DMD


Capricor Therapeutics is expanding the development of exosome-based technologies that are being tested as a potential way to treat Duchenne muscular dystrophy (DMD).

Capricor’s lead candidate for DMD is CAP-1002, which is composed of cardiosphere-derived cells (CDCs). These are cardiac progenitor cells, meaning they are able to grow and differentiate into mature heart cells. They have shown regenerative properties and an ability to limit inflammation and scarring.

Results from the Phase 1/2 HOPE clinical trial (NCT02485938) showed that one-time administration of CAP-1002 directly into the heart improved heart muscle function in people with DMD. In addition, it improved arm and hand strength and reduced cardiac scarring. The therapy is being further evaluated in the Phase 2 clinical trial HOPE-2 (NCT03406780), which is testing one-year treatment in boys and men on standard-of-care therapy.

 

Capricor Therapeutics Expands Exosome Technology For DMD