Dietary supplement increases muscle force by 50% in the Duchenne muscular dystrophy mouse model | DuchenneXchange

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Dietary supplement increases muscle force by 50% in the Duchenne muscular dystrophy mouse model


Duchenne muscular dystrophy (DMD) is a hereditary disease characterized by progressive muscle degeneration. The disease puts affected people in a wheelchair by their teens. It also affects the heart and respiratory muscles, reducing the life expectancy of patients to less than 40 years. DMD affects roughly 1 out of 3,500 boys, making it the most common form of muscular dystrophy. There is no known cure for the disease. A steroid-based treatment can slow down muscle degeneration, but it causes serious side effects.

“People have a lot of hope for gene therapy, but it will still take years of research before we find an effective treatment,” explains lead author Professor Sachiko Sato. “That’s why it’s important to find other treatments to help preserve the muscular strength of patients as long as possible.”

Professor Sato and her collaborators tested N-acetylglucosamine, a glucose derivative used as a dietary supplement, on mice showing the main symptoms of DMD.

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