Pathway Key to Muscle Regeneration Doesn’t Work as It Should in Duchenne, Study Finds | DuchenneXchange

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Pathway Key to Muscle Regeneration Doesn’t Work as It Should in Duchenne, Study Finds


The Hippo signaling pathway — a key regulator of tissue development, and cell growth and death — does not work as it should in Duchenne muscular dystrophy and acts to prevent, rather than aid, the regeneration of muscle cells in DMD patients, a study reports.

A member of this pathway, a protein called YAP1, is an important regulator of muscle repair and regeneration after injury, and researchers suggest it could be a target for future Duchenne therapies. Interestingly, similar pathway dysregulation was not seen in other muscular dystrophies.

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