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Dongsheng Duan, PhD

University of Missouri School of Medicine
M610G Medical Sciences Building
Columbia, Missouri, United States

Dr. Dongsheng Duan is Professor at University of Missouri and specializes in Molecular Microbiology, Immunology and Neurology. He completed his PhD from University of Pennsylvania. He is an expert of gene therapy, neuromuscular biology, virology and molecular therapies. His research interests are recombinant adeno-associated virus (rAAV) transduction biology, Duchenne muscular dystrophy (DMD) gene therapy, Duchenne cardiomyopathy, canine model of muscular dystrophy and free radical in muscle function and aging.

Dr. D. Duan has greatly contributed in the field of DMD research. His goal is to develop gene therapies to fight DMD. He aims to deliver the dystrophin gene back into the diseased muscles through gene therapy approach.


Representative Publications:

Micro-dystrophin gene therapy goes systemic in Duchenne muscular dystrophy patients

Variable rescue of microtubule and physiological phenotypes in mdx muscle expressing different miniaturized dystrophins

Automatic quantification of microscopic heart damage in a mouse model of Duchenne muscular dystrophy using optical polarization tractography

Nanotherapy for Duchenne muscular dystrophy

Cardiac-Specific Expression of ΔH2-R15 Mini-Dystrophin Normalized All Electrocardiogram Abnormalities and the End-Diastolic Volume in a 23-Month-Old Mouse Model of Duchenne Dilated Cardiomyopathy

A new kid on the playground of CRISPR DMD therapy

CRISPR-Cas9 cleavage efficiency correlates strongly with target-sgRNA folding stability: from physical mechanism to off-target assessment

Dystrophin gene replacement and gene repair therapy for Duchenne muscular dystrophy in 2016

In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy