Karen Anthony, PhD, FHEA, PgCert | DuchenneXchange

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Researchers

Karen Anthony, PhD, FHEA, PgCert

Researcher
Senior Lecturer in Molecular Bioscience
Molecular Biosciences Research Group Lead
Faculty of Health and Society
University of Northampton
University Drive
Northampton, United Kingdom

Dr. Karen Anthony is currently working as senior lecturer in Molecular Bioscience at University of Northampton. She is a leading researcher on RNA processing and RNA-based therapeutics. Karen has worked on a number of neurological drug and disease targets including tau and TDP-43 for Alzheimer’s and motor neurone disease.

Her ongoing work is focused on the neuromuscular disorder, Duchenne muscular dystrophy (DMD). Karen played a key role in the clinical development of the first FDA-approved drug for DMD, an antisense oligonucleotide called Exondys 51 (eteplirsen).

She has developed, optimised and validated standardised protocols to accurately quantify dystrophin mRNA and protein in clinical trials and has helped international pharmaceutical companies with methodology for clinical trial biochemical outcome measures. Karen’s pre-clinical and clinical work in this area is helping to expedite the translation of exon skipping candidate drugs to the clinic.

 

Representative Publications:

Exon skipping quantification by quantitative reverse-transcription polymerase chain reaction in Duchenne muscular dystrophy patients treated with the antisense oligomer eteplirsen

Antisense oligonucleotide-mediated exon skipping for Duchenne muscular dystrophy: progress and challenges

Restoration of the dystrophin-associated glycoprotein complex after exon skipping therapy in Duchenne muscular dystrophy

Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study

Brain involvement in Duchenne muscular dystrophy: a role for dystrophin isoform Dp71 in cell migration and proliferation

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