Matthew Wood, PhD | DuchenneXchange

welcome to DuchenneXchange

- a positively charged Duchenne muscular dystrophy community.
  • join today!
Researchers

Matthew Wood, PhD

Researcher
Professor of Neuroscience
University of Oxford
Department of Physiology, Anatomy and Genetics
Sherrington Building
Parks Road
Oxford, United Kingdom

Matthew Wood is Professor of Neuroscience, Department of Physiology, Anatomy and Genetics and Fellow of Somerville College in the University of Oxford.

Wood’s research is in the field of gene therapy for degenerative disorders of the nervous system and muscle. The main focus is the investigation of novel therapeutic approaches utilising short nucleic acids to target messenger RNA.

His current work is about investigating the potential of single-stranded antisense oligonucleotides for the modification of mRNA splicing, for example in Duchenne muscular dystrophy. In addition, the potential of double-stranded RNA for gene silencing, known as RNA interference (RNAi), is being investigated for the silencing of target genes and mutant alleles both in muscle and in the nervous system.

 

Representative Publications:

Biomarker Potential of Extracellular miRNAs in Duchenne Muscular Dystrophy

Corrigendum: Identification of novel, therapy-responsive protein biomarkers in a mouse model of Duchenne muscular dystrophy by aptamer-based serum proteomics

Stakeholder cooperation to overcome challenges in orphan medicine development: the example of Duchenne muscular dystrophy

Bi-specific splice-switching PMO oligonucleotides conjugated via a single peptide active in a mouse model of Duchenne muscular dystrophy

Current understanding of molecular pathology and treatment of cardiomyopathy in duchenne muscular dystrophy

Implications for Cardiac Function Following Rescue of the Dystrophic Diaphragm in a Mouse Model of Duchenne Muscular Dystrophy

rareRelated