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Researchers

Michael A. Rudnicki, PhD

Researcher
Senior Scientist and Director, Regenerative Medicine Program
Ottawa Hospital Research Institute
501 Smyth Box 511
Ottawa, Canada

Dr. Michael Rudnicki is a Senior Scientist and the Director of the Regenerative Medicine Program and the Sprott Centre for Stem Cell Research at the Ottawa Hospital Research Institute. He is Professor in the Department of Medicine at the University of Ottawa and the Scientific Director of the Canadian Stem Cell Network.

Dr. Rudnicki is an Officer of the Order of Canada, a Fellow of the Royal Society of Canada, and holds the Canada Research Chair in Molecular Genetics. He is an Associate Editor of Cell Stem Cell and the Journal of Cell Biology, and is Co-Editor in Chief of Skeletal Muscle. He has organized international research conferences as one of the founding directors of the Society for Muscle Biology.

Dr Rudnicki’s laboratory works to understand the molecular mechanisms that regulate the determination, proliferation, and differentiation of stem cells during embryonic development and during tissue regeneration. His lab has conducted leading studies into both embryonic myogenesis and the function of muscle stem cells (satellite cells) in adult regenerative myogenesis. In particular, they have worked extensively to understand the molecular mechanisms that regulate the function of satellite cells in skeletal muscle. His research interests include the population affected with muscular dystrophy and neuromuscular disease.

 

Representative Publications:

Pax7 is required for the specification of myogenic satellite cells

Asymmetric self-renewal and commitment of satellite stem cells in muscle

Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells

MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16

Inhibition of JAK/STAT signaling stimulates adult satellite cell function

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