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Aerobic Exercise in Duchenne Muscular Dystrophy

key information

study id #: NCT04173234

condition: Duchenne Muscular Dystrophy

status: recruiting


Duchenne Muscular Dystrophy (DMD) is the most common neuromuscular disease in childhood with an estimate incidence of 1 in 3500 to 5000 male births. The effect of aerobic training on muscle architectural properties and motor functions such as muscle activation is not clear in DMD. The aim of this study is to compare with children with DMD and healthy peers in terms of muscle architectural properties and motor functions, and investigate the effects of aerobic training on these parameters in children with DMD. Twenty children with DMD and 10 healthy peers will be included in the study. Twenty children with DMD included in the study will be divided into two groups as home program and home program+aerobic training with block randomization method. Home program including stretching, respiratory, range of motion and mild resistance exercise with body weight will be asked to apply 3-5 days a week for 12 weeks, aerobic training will be performed 3 days a week for 12 weeks at 60% of their maximum hearth rate with 50 minutes total duration consisting of 10 min warm up and 10 min cool down period. Muscle architectural properties, muscle strength, muscle activation and motor function will be assessed with ultrasonographic, hand-held myometry, surface EMG and Motor Function Measure, consecutively. Assessments will be applied at pre-training and after 12 weeks of training.

intervention: Aerobic Training, Home exercise program

mechanism of action: No pharmaceutical intervention

results: https://clinicaltrials.gov/ct2/show/results/NCT04173234

last updated: February 04, 2020