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CoQ10 and Prednisone in Non-Ambulatory DMD

key information

study id #: NCT00308113

condition: Duchenne Muscular Dystrophy

status: terminated


This study will help determine if CoQ10 and prednisone, alone and as a combination decrease the decline in cardiopulmonary and skeletal muscle function that occurs in the wheelchair confined phase of DMD. Participants who are enrolled in this study should not have taken any corticosteroids within the last six months. This is a 13-month, prospective, randomized study comparing a daily prednisone arm (0.75mg/kg/day), a CoQ10 arm (serum of greater than 2.5 ug/mL) and a combination arm (prednisone and CoQ10) with an enhanced standard of care arm in wheelchair confined males age 10 to 18 years with an established DMD diagnosis.

intervention: Prednisone, Coenzyme Q10

mechanism of action: Glucocorticoid to delay decline in muscle strength; Antioxidant to reduce inflammation

results: https://clinicaltrials.gov/ct2/show/results/NCT00308113

last updated: November 21, 2018