welcome to DuchenneXchange- a positively charged Duchenne muscular dystrophy community.
- join today!
Improved Muscle Function in Duchenne Muscular Dystrophy Through L-Arginine and Metformin
study id #: NCT02516085
condition: Duchenne Muscular Dystrophy
The purpose of the study is to show that the intake of L-arginine and metformin improves muscle function and delays disease progression in patients with Duchenne’s muscular dystrophy.
intervention: Metformin, L-Arginine
mechanism of action: Muscle cell engery regulators to prevent muscle loss
last updated: November 22, 2018
start date: January 2012
estimated completion: October 2012
phase of development: Phase 1
size / enrollment: 5
This is an investigator-initiated, open-label, single-center, proof-of-concept-study. The study medication consists of L-arginine and metformin. The duration of the study is 16 weeks and comprehends one screening and four study visits.
- Mean change of muscle metabolism [ Time Frame: baseline to week 16 ]
mitochondrial protein expression analysis in muscular biopsies
- In vivo change of muscle metabolism [ Time Frame: baseline to week 16 ]
indirect calorimetry, Dual-Energy X-Ray Absorptiometry, quantitative thigh muscle MRI, clinical score of muscle performance
• Molecular diagnosis of DMD
• Patients 7 - 10 years of age at time of screening
• Previous (3 months or less) or concomitant participation in another therapeutic trial
• Use of L-arginine, L-citrulline or metformin within the last 3 months
• Known individual hypersensitivity to L-citrulline or metformin
• Other chronic disease or clinical relevant limitation of renal, liver, heart function according to discretion of the investigator
ReveraGen Announces First Patient Enrollment in International Pivotal Trial of Vamorolone in Duchenne Muscular Dystr...ReveraGen BioPharma, Inc. today announce...
A Phase I/II Study of BMN053 in Subjects With Duchenne Muscular Dystrophy (DMD)The purpose of the study is to see wheth...
Safety Study of Flavocoxid in Duchenne Muscular DystrophyObjective of this study is to evaluate s...
A Double-blind, Escalating Dose, Randomized, Placebo-controlled Study Assessing PK, Safety, Tolerability in Non-ambu...The purpose of this study is investigate...
A Pharmacokinetic Study of Oral Deflazacort in Children and Adolescent Subjects With Duchenne Muscular DystrophyStudy to characterize the single-state a...
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of a Single Dose of SRP-5051 in Patients With Duc...The purpose of this study is to evaluate...
Effect of a long-term treatment with metformin in dystrophic mdx mice: A reconsideration of its potential clinical i...The pharmacological stimulation of AMP-a...
Wave Life Sciences Receives US Orphan Drug and Rare Pediatric Disease Designations for WVE-210201Wave Life Sciences Ltd., a biotechnology...
Phase 1 Study of Edasalonexent (CAT-1004), an Oral NF-κB Inhibitor, in Pediatric Patients with Duchenne Muscular Dy...Background: Edasalonexent is an orally ...
Sarepta Therapeutics to Provide Update on Duchenne Muscular Dystrophy Gene Therapy ProgramSarepta Therapeutics, Inc., the leader i...