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Lower Limb Flexibility in Duchenne Muscular Dystrophy: Effects on Functional Performance

key information

study id #: NCT03534349

condition: Duchenne Muscular Dystrophy, Performance, Flexibility

status: completed


The investigator investigated the effect of lower limb flexibility on functional performance of children with Duchenne Muscular Dystrophy.

mechanism of action: No pharmaceutical intervention

results: https://clinicaltrials.gov/ct2/show/results/NCT03534349

last updated: November 21, 2018

study details

start date: January 2017

estimated completion: June 2017

size / enrollment: 30

study description:
Thirty children whose functional levels were in 1 or 2 according to the Brooke Lower Extremity Functional Classification Scale were included in the study. Flexibilities of hamstrings, hip flexors, tensor fascia latae, and gastrocnemius muscles were evaluated in dominant lower limb. Popliteal angle test, hip flexor flexibility test, tensor fascia latae flexibility test and gastrocnemius flexibility test were used for flexibility asssessments. Functional performance was assessed with 6 Minute Walk Test (6 MWT) and Timed Performance Tests. The correlation between the flexibility of lower limb muscles' and performance tests were examined.

primary outcomes:

  • 6 Minute Walk Test [ Time Frame: 6 Minute ]
    The 6 Minute Walk Test (6MWT) is a standard test recently used to evaluate functional capacity in neuromuscular diseases, and found to be a safe and valid test that can be performed in Duchenne Muscular Dystrophy

secondary outcomes:

  • Timed Performance Test [ Time Frame: 3 minute ]
    Timed performance tests such as 10 m walk, Gower's (from supine position to stand up), ascending/descending 4 steps were also performed. During these tests, the child's performance was recorded in seconds.

inclusion criteria:

• Eligible Sexes:

• Having a Duchenne Muscular Dystrophy diagnosis,
• Being in the ambulatory period and climbing four steps independently,
• To be able to cooperate the physiotherapist's directions,
• Not having any severe contracture in the lower limbs which may prevent assessments,
• Not having any injury or surgery involving the lower limbs during the last 6 months.

exclusion criteria:
Children who did not provide these criteria and did not will to participate the study were excluded.

study contacts

sponsor: Hacettepe University

investigators: Assoc. Prof. Pek Alemdaroğlu Gürbüz; Prof. Ayşe Karaduman

trial center locations: Turkey