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PDE Inhibitors in DMD Study (Acute Dosing Study)

key information

study id #: NCT01580501

condition: Duchenne Muscular Dystrophy

status: completed


PDE5A inhibition, which boosts NO-cGMP signaling, will relieve functional muscle ischemia and restore normal blood flow regulation (i.e., functional sympatholysis) during exercise in boys with DMD. The investigators specific aim is to perform an efficient dose-titration study to inform the design of a randomized multicenter trial of PDE5A inhibition for clinical skeletal muscle and cardiac endpoints.

intervention: Tadalafil and Sildenafil

mechanism of action: PDE5 inhibitor to improve muscle blood flow during exercise

results: https://clinicaltrials.gov/ct2/show/results/NCT01580501

last updated: November 21, 2018