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Peak Cough Flow and Cough Clearance in Patients With Muscular Dystrophy

key information

study id #: NCT02034305

condition: Duchenne Muscular Dystrophy

status: recruiting


This study is to determine whether physiologic measures (peak cough flow, measures of respiratory muscle strength including MIP, MEP, SNIP, and spirometry) can predict spontaneous cough clearance (as measured by a nuclear medicine study) in children with neuromuscular disease. It will also determine whether airway clearance is augmented by high frequency chest wall oscillation.

mechanism of action: No pharmaceutical intervention

results: https://clinicaltrials.gov/ct2/show/results/NCT02034305

last updated: February 15, 2019

study details

start date: January 2014

estimated completion: January 2020

size / enrollment: 15

primary outcomes:

  • Spontaneous cough clearance [ Time Frame: Assessed at multiple time points over 30 minutes ]

inclusion criteria:

• Eligible Sexes:

• Age 6-21; able to cooperate with study procedures
• Duchenne Muscular Dystrophy OR Becker Muscular Dystrophy

exclusion criteria:
• Need for mechanical ventilation during the day
• Recent (within 2 weeks) lower respiratory tract infection

study contacts

sponsor: University of Pittsburgh

contacts: Paul Rebovich (MS), 412-692-5873, Paul.rebovich@chp.edu

investigators: Daniel J. Weiner, MD

trial center locations: United States