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Peak Cough Flow and Cough Clearance in Patients With Muscular Dystrophy
study id #: NCT02034305
condition: Duchenne Muscular Dystrophy
This study is to determine whether physiologic measures (peak cough flow, measures of respiratory muscle strength including MIP, MEP, SNIP, and spirometry) can predict spontaneous cough clearance (as measured by a nuclear medicine study) in children with neuromuscular disease. It will also determine whether airway clearance is augmented by high frequency chest wall oscillation.
mechanism of action: No pharmaceutical intervention
last updated: December 04, 2019
start date: January 2014
estimated completion: January 2020
size / enrollment: 15
- Spontaneous cough clearance [ Time Frame: Assessed at multiple time points over 30 minutes ]
• Age 6-21; able to cooperate with study procedures
• Duchenne Muscular Dystrophy OR Becker Muscular Dystrophy
• Need for mechanical ventilation during the day
• Recent (within 2 weeks) lower respiratory tract infection
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