Peak Cough Flow and Cough Clearance in Patients With Muscular Dystrophy | DuchenneXchange

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Peak Cough Flow and Cough Clearance in Patients With Muscular Dystrophy

key information

study id #: NCT02034305

condition: Duchenne Muscular Dystrophy

status: recruiting

purpose:

This study is to determine whether physiologic measures (peak cough flow, measures of respiratory muscle strength including MIP, MEP, SNIP, and spirometry) can predict spontaneous cough clearance (as measured by a nuclear medicine study) in children with neuromuscular disease. It will also determine whether airway clearance is augmented by high frequency chest wall oscillation.

mechanism of action: No pharmaceutical intervention

results: https://clinicaltrials.gov/ct2/show/results/NCT02034305

study details

start date: January 2014

estimated completion: January 2019

size / enrollment: 15

primary outcomes:

  • Spontaneous cough clearance [ Time Frame: Assessed at multiple time points over 30 minutes ]

inclusion criteria:
• Age 6-21; able to cooperate with study procedures
• Duchenne Muscular Dystrophy OR Becker Muscular Dystrophy

exclusion criteria:
• Need for mechanical ventilation during the day
• Recent (within 2 weeks) lower respiratory tract infection

study contacts

sponsor: University of Pittsburgh

contacts: Paul Rebovich (MS), 412-692-5873, paul.rebovich@chp.edu

investigators: Daniel J. Weiner, MD

locations: United States