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rareClinical
unknown status

Pediatric Radio Frequency Coils Generic

key information

study id #: NCT01633866

condition: Duchenne Muscular Dystrophy, Musculoskeletal Abnormalities

status: unknown

purpose:

The purpose of this study is to evaluate and optimize advances in radio frequency (RF) coil magnetic resonance imaging (MRI) technology at Cincinnati Children’s Hospital Medical Center (CCHMC).

mechanism of action: No pharmaceutical intervention

results: https://clinicaltrials.gov/ct2/show/results/NCT01633866

last updated: November 22, 2018

study details

start date: July 2012

estimated completion: June 2017

size / enrollment: 75

study description:
Pediatric Magnetic resonance (MR) imaging techniques have been limited by the unavailability of specialized radio-frequency (RF) coils for pediatric imaging. Typically, MR coils are designed for general purpose adult imaging and lack the mechanical design, flexibility and high channel count needed for pediatric imaging. Furthermore, pediatric patients are often positioned decubitus or prone rather than supine. This makes coil positioning even more challenging and often results in images with low SNR and poor image quality. Many coils used in clinical practice have fixed dimensions that do not fit within the realm of "one-size fits all," especially for the huge variation found in the pediatric patient population.
MRI coil development and optimization is performed by MR manufacturers and in research laboratories across the world including the Imaging Research Center (IRC) of Cincinnati Children's Hospital and Medical Center (CCHMC). Coil development and refinement involves evaluating the new coils on inert phantoms and then imaging examinations performed on healthy participants and patients. The focus of this study protocol is to evaluate the design and performance of investigational coils on patients and healthy participants.

primary outcomes:

  • Number of participants with adverse events as measured by heating and comfort participant response [ Time Frame: Day 1 ]

secondary outcomes:

  • MRI Image Quality [ Time Frame: 2 Weeks Post MRI Scan ]

inclusion criteria:
Healthy participants:
• Male or Female
• Thermally stable
• Any age
Clinical patients:
• Male or Female
• Thermally stable
• any age

exclusion criteria:
Healthy participants & Clinical patients
• Female participants who are pregnant or lactating
• Subjects with standard contraindications to MRI

study contacts

sponsor: Children's Hospital Medical Center, Cincinnati

contacts: Kansie E Somers (MA), 513-636-9403, kansie.somers@cchmc.org

investigators: Charles Dumoulin, PhD

locations: United States

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