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Pulmonary and Upper Limb Functions in Duchenne Muscular Dystrophy

key information

study id #: NCT03552874

condition: Duchenne Muscular Dystrophy, Upper Limb Function, Respiratory Function Test

status: completed


Although it is known that the functions of pulmonary and upper limb is affected in late stage of Duchenne Muscular Dystrophy (DMD) negatively, the investigators do not have clear information about its early stage. The aim of this study was to investigate the differences in pulmonary and upper limb functions between children with DMD in early stage and healthy peers.

intervention: The Performance of Upper Limb Questionnaire (PUL)

mechanism of action: No pharmaceutical intervention

results: https://clinicaltrials.gov/ct2/show/results/NCT03552874

last updated: January 08, 2019

study details

start date: January 1, 2017

estimated completion: March 31, 2018

size / enrollment: 47

primary outcomes:

  • Pulmonary Function Test (PFT) [ Time Frame: 5 minutes ]
    The pulmonary function tests of the participants were evaluated with a spirometry. The child was asked to perform the spirometric tests for three times with maximum effort. The child was motivated before each attempt for stronger and longer expiration.The result of Pulmonary function Test were recorded.
  • The Performance Upper Limb (PUL) [ Time Frame: 15 minutes ]
    Upper limb functions of participants were evaluated with The Performance of Upper Limb (PUL) scale. This scale, which was shown to be reliable in DMD, has 22 items in total. It consists of 3 different levels of function: high, mid, and distal. PUL also has four items determining timed performance.

inclusion criteria:
Children with DMD were;
• age between 5-10 years
• being on treatment with corticosteroids for more than 6 months
• being at Level I according to Brooke Upper and Lower Extremity Classification Systems
Healthy peers;
• age between 5-10 years
• not having any diagnosed disease

exclusion criteria:
Children has undergo surgery and disease affect upper extremity or pulmonary function in last six months.

study contacts

sponsor: Hacettepe University

investigators: Numan Bulut, Hacettepe University