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Spironolactone Versus Prednisolone in DMD

key information

study id #: NCT03777319

condition: Muscular Dystrophy, Duchenne

status: recruiting

purpose:

This is a randomized, open-label, pilot clinical trial of spironolactone suspension versus oral prednisolone for use in Duchenne muscular dystrophy. The goals are to determine the safety of 6 months of treatment with spironolactone treatment int he steroid-naive DMD population as well as to determine if either spironolactone or a standard clinical dose of corticosteroids results in equivalent improvement in time to complete the 100 meter timed test (100M).

intervention: Spironolactone, Prednisolone

mechanism of action: Aldosterone-blocking diuretic to delay decline in muscle strength and prevent cardiovascular strain

results: https://clinicaltrials.gov/ct2/show/results/NCT03777319

last updated: December 04, 2019