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Weekend Steroids and Exercise as Therapy for DMD

key information

study id #: NCT04322357

condition: Duchenne Muscular Dystrophy (DMD)

status: not yet recruiting

purpose:

The study team will determine the potential of low dose weekend prednisone and whether exercise training can synergize to delay disease progression and improve muscle strength/physical function in boys with Duchenne muscular dystrophy (DMD). Current standard of care (daily prednisone) is associated with adverse side effects. Evidence from DMD mouse models suggest that weekend dosing provides same efficacy without side effects. Appropriate exercise may also benefit but this area has not been adequately explored.

intervention: Drug: Prednisone, Behavioral: In-home Exercise Training

mechanism of action: Glucocorticoid to delay decline in muscle strength

results: https://clinicaltrials.gov/ct2/show/results/NCT04322357

last updated: April 09, 2020