The Relationship between Bone Mineral Density and Cardiovascular Function in Duchenne Muscular Dystrophy: A Retrospective Cohort Study | DuchenneXchange

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Abstracts & Posters

The Relationship between Bone Mineral Density and Cardiovascular Function in Duchenne Muscular Dystrophy: A Retrospective Cohort Study

key information

source: American Academy of Neurology

year: 2016

authors: Tara A. Kervin, Mathula Thangarajh

summary/abstract:

Objective:
The objective of this retrospective cohort study is to examine the relationship between bone mineral density (BMD) and cardiovascular health in patients with Duchenne muscular dystrophy (DMD).

Background:
DMD is a genetic disorder, affecting boys that cause progressive muscle weakness. Cardiac dysfunction is a frequent cause of death in DMD. The long-term use of oral corticosteroids to delay the progression of muscle weakness in DMD is complicated by poor bone health. Epidemiological studies have suggested a biological link between the loss of BMD and cardiovascular disease, including coronary artery disease and cerebrovascular events. Whether an association between low BMD and cardiac dysfunction occurs in DMD boys has not yet been studied.

Methods:
Data on DMD patients was collected retrospectively from patient records dated 2010 2014 at Children’s National Medical Center in Washington, D.C. Whole body BMD was measured using DEXA scan and left ventricular ejection fraction (LVEF) was measured using echocardiogram. Linear regression was used to evaluate the relationship between BMD and LVEF.

Results:
This analysis included 32 boys with DMD who had BMD baseline measurements at a mean age of 11±3 (SD) years with the worst LVEF measured a mean 23.7±21.8 (SD) months after baseline. The final adjusted linear regression of the relationship between baseline BMD Z-score and worst LVEF was not statistically significant (R2=0.1460, ß=0.41, p-value=0.6455).

Conclusions:
In this cohort of boys with DMD, BMD was not associated with LVEF dysfunction up to 79 months later. Future research with more longitudinal follow-up is suggested.

organisation: Statistics Collaborative, Inc., USA

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